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Association of inflammatory factors and aging in Parkinson's disease.
Neuroscience Letters ( IF 2.5 ) Pub Date : 2020-07-16 , DOI: 10.1016/j.neulet.2020.135259
Hong Jin 1 , Han-Ying Gu 1 , Cheng-Jie Mao 1 , Jing Chen 1 , Chun-Feng Liu 2
Affiliation  

Background

Parkinson's disease as a common neurodegenerative disease, has been found to be related to inflammation. So we observed the characteristics of inflammatory indexes in patients with Parkinson's disease and investigated the relationship between inflammatory cytokines and clinical characteristics. Emerging data may reveal novel neuroinflammatory pathways and identify new targets for treatment of Parkinson's disease.

Methods

We examined the inflammatory indexes in 183 patients and 89 healthy controls in association with clinical characteristics.

Results

Patients had significantly higher levels of monocytes, neutrophils, high-sensitivity C-reactive protein, and monocyte-to-high-density lipoprotein ratios (p < 0.01) and lower levels of lymphocytes (p = 0.02) than the controls. There were no significant differences in age, leukocytes, high-density lipoprotein, or neutrophil-lymphocyte ratios between the two groups (p > 0.05). Multivariate logistic regression analysis of these indicators revealed that lymphocyte level was a protective factor (p = 0.025, OR=-0.679), while high-sensitivity C-reactive protein level was a risk factor (p = 0.000, OR=1.168) for Parkinson's disease. High-sensitivity C-reactive protein levels were higher in older Parkinson's disease patients.

Conclusion

High-sensitivity C-reactive protein is positively related to the risk of Parkinson's disease, especially in aging patients. High-sensitivity C-reactive protein is a potential biomarker for disease progression and treatment response for Parkinson's disease.



中文翻译:

帕金森氏病中炎症因子与衰老的关系。

背景

帕金森氏病是一种常见的神经退行性疾病,已发现与炎症有关。因此,我们观察了帕金森氏病患者炎症指标的特征,并研究了炎症细胞因子与临床特征之间的关系。新兴数据可能揭示了新的神经炎症途径,并确定了治疗帕金森氏病的新靶标。

方法

我们结合临床特点检查了183例患者和89例健康对照者的炎症指标。

结果

与对照组相比,患者的单核细胞,中性粒细胞,高敏感性C反应蛋白,单核细胞与高密度脂蛋白之比水平显着较高(p  <0.01),而淋巴细胞水平较低(p  = 0.02)。两组之间的年龄,白细胞,高密度脂蛋白或中性白细胞-淋巴细胞比率无显着差异(p  > 0.05)。这些指标的多因素逻辑回归分析显示,淋巴细胞水平是一个保护因素(p  = 0.025,OR = -0.679),而高敏C反应蛋白水平是一个危险因素(p = 0.000,或= 1.168)。帕金森氏病老年患者的高敏感性C反应蛋白水平较高。

结论

高敏C反应蛋白与帕金森氏病的风险呈正相关,特别是在老年患者中。高敏C反应蛋白是疾病进展和帕金森氏病治疗反应的潜在生物标志物。

更新日期:2020-07-30
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