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Into the Unknown: A Chemical Biology Approach Provides Mechanistic Insight into HCV Entry.
Cell Chemical Biology ( IF 8.6 ) Pub Date : 2020-07-16 , DOI: 10.1016/j.chembiol.2020.06.018
Fang Chen 1 , Luke L Lairson 2 , Mansun Law 1
Affiliation  

In this issue of Cell Chemical Biology, Hu et al. (2020) demonstrate that chlorcyclizine blocks HCV fusion by targeting the putative fusion peptide on the viral envelope glycoprotein E1. The study provides new insights into the viral fusion machinery, presenting an opportunity to study novel antivirals against HCV.



中文翻译:

走进未知世界:化学生物学方法为HCV进入提供了机械的见解。

在本期《细胞化学生物学》中,Hu等人。(2020)证明氯环嗪通过靶向病毒包膜糖蛋白E1上的假定融合肽来阻断HCV融合。该研究提供了对病毒融合机制的新见解,为研究针对HCV的新型抗病毒药提供了机会。

更新日期:2020-07-16
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