OBJECTIVE To describe the course of performance of activities (observed and self-reported) of people with Chronic Idiopathic Axonal Polyneuropathy (CIAP) over four years and to assess the associations with muscle strength, sensory function and psychological personal factors (intention, perceived behaviour control (PBC) and feelings of depression or anxiety). DESIGN Prospective observational study with measurement at baseline, six months, one year and four years. SETTING Outpatient neurology clinic PARTICIPANTS: People with CIAP (N = 92) MAIN OUTCOME MEASURE(S): Walking was measured using the shuttle walk test (SWT), a pedometer (mean step count a day) and the subscale 'physical functioning (PF)' of the short-form 36 questionnaire. Muscle strength and sensory function were measured using a MicroFET ® hand-held dynamometer (HHD) and the Sensory Modality Sum score (SMS). Personal factors were assessed with the Hospital Anxiety and Depression Scale (HADS), and intention and PBC with a protocolized questionnaire. RESULTS Multilevel model analysis showed a significant decrease over time in mean scores in performance of activities (SWT, step count) which was associated with older age and loss of muscle strength (SWT: b = 73.392, step count: b = 676.279, p <.001). Limitations in self-reported functioning (PF) significantly increased and were associated with older age (b = -0.916, p = 0.001), increased comorbidity (b = -6.978, p = 0.024), loss of muscle strength (b = 7.074, p < 0.001), low PBC (b= 0.744, p < 0.001) and increased feelings of depression (b = 1.481, p < 0.001). CONCLUSION Performance of activities of people with CIAP decreased over time (SWT, step count, PF). Older age, loss of muscle strength, comorbidity, feelings of depression and low perceived behavior control were associated with this decrease. However, there were considerable individual differences.

中文翻译：

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慢性特发性轴索性多发性神经病 (CIAP) 患者的表现和自我报告的功能：一项为期四年的随访研究

目的 描述慢性特发性轴索性多发性神经病 (CIAP) 患者四年来的活动表现（观察和自我报告）过程，并评估与肌肉力量、感觉功能和心理个人因素（意图、感知行为控制）的关联。 (PBC) 和抑郁或焦虑的感觉）。设计 前瞻性观察研究，在基线、六个月、一年和四年时进行测量。设置门诊神经内科诊所参与者：CIAP 患者（N = 92） 主要结果测量：使用穿梭步行测试 (SWT)、计步器（每天平均步数）和分量表“身体机能（PF）”测量步行)' 的简短形式 36 问卷。使用 MicroFET ® 手持式测力计 (HHD) 和感觉模态总和评分 (SMS) 测量肌肉力量和感觉功能。使用医院焦虑和抑郁量表 (HADS) 评估个人因素，并使用协议化问卷评估意图和 PBC。结果 多水平模型分析显示活动表现（SWT，步数）的平均得分随时间显着下降，这与年龄较大和肌肉力量丧失有关（SWT：b = 73.392，步数：b = 676.279，p < .001）。自我报告功能 (PF) 的限制显着增加并与年龄较大 (b = -0.916, p = 0.001)、合并症增加 (b = -6.978, p = 0.024)、肌肉力量丧失 (b = 7.074, p < 0.001)、低 PBC (b = 0.744, p < 0.001) 和抑郁感增加 (b = 1.481, p < 0. 001）。结论 CIAP 患者的活动表现随时间下降（SWT、步数、PF）。年龄较大、肌肉力量丧失、合并症、抑郁感和低感知行为控制与这种下降有关。然而，存在相当大的个体差异。