Neuropathy and primary headaches affect different subgroups of inflammatory bowel disease patients.,Neurological Sciences

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Neuropathy and primary headaches affect different subgroups of inflammatory bowel disease patients.
Neurological Sciences ( IF 3.3 ) Pub Date : 2020-07-15 , DOI: 10.1007/s10072-020-04596-y
Antônio M F Leitão _{1,

2} , Howard L Ribeiro Junior _{3,

4} , Davi F Araújo ₁ , Lúcia L B C Braga ₅ , Marcellus H L P Souza ₅ , Alzira M C Barbosa ₅ , Antônio B Viana Júnior ₅ , Francisco De A A Gondim ₅

Affiliation

Background

Peripheral neuropathies (PN) and primary headaches (PH) are common comorbidities in inflammatory bowel disease (IBD) patients. We aimed to evaluate whether PN and PH affect the same subgroups of IBD patients.

Methods

Since 2004, we established a cohort study to evaluate neurological diseases in IBD patients. Over 2 years, all consecutive (N = 155) IBD patients (either Crohn’s disease (CD) or ulcerative colitis (UC) were evaluated for the presence of PN and PH. PH were also evaluated in dyspeptic patients (N = 84) and IBD relatives (controls, N = 101). After neurological evaluation, symptomatic patients underwent skin wrinkling test to evaluate small fiber function and/or electromyography.

Results

Headaches and migraine were more prevalent in IBD than control patients: 52.3 and 34.2% vs. 40.6 and 20.8% (P < 0.05). Migraine was 2.6 times more common in CD patients than controls (CI = 1.34–5.129) and 8.6 times (13.3 times in the CD group) more common in men with IBD (P < 0.05). Headache and migraine were also more common in dyspeptic patients (P < 0.05). Chi-square, univariate, and multivariate regression analysis did not disclose any association between PN, headache, or PH (P > 0.05). Multivariate regression analysis disclosed that headaches were more prevalent in women, co-existing psychiatric disease, IBD, CD, and UC. After age, gender distribution, and prevalence of hypertension and psychiatric diseases were matched among the groups, there were still differences in the prevalence of headaches and migraine among IBD, CD, and UC versus control patients.

Conclusion

In summary, PH and PN are common in IBD and do not affect the same subgroups of patients.

中文翻译：

神经病和原发性头痛会影响炎症性肠病患者的不同亚组。

背景

周围神经病变（PN）和原发性头痛（PH）是炎性肠病（IBD）患者的常见合并症。我们旨在评估PN和PH是否会影响IBD患者的同一亚组。

方法

自2004年以来，我们建立了一项队列研究来评估IBD患者的神经系统疾病。在2年中，对所有连续（N = 155）IBD患者（克罗恩病（CD）或溃疡性结肠炎（UC））进行PN和PH评估。消化不良患者（N = 84）和IBD也评估了PH亲属（对照组，N = 101）。经过神经系统评估后，有症状的患者进行了皮肤起皱测试，以评估小纤维功能和/或肌电图。

结果

IBD中头痛和偏头痛的发生率高于对照组：52.3％和34.2％，而40.6％和20.8％（P <0.05）。CD患者的偏头痛发生率比对照组（CI = 1.34–5.129）高2.6倍，IBD男性的偏头痛发生率比对照组高8.6倍（CD组为13.3倍）（P <0.05）。消化不良患者的头痛和偏头痛也更为常见（P <0.05）。卡方，单变量和多元回归分析未揭示PN，头痛或PH之间的任何关联（P > 0.05）。多元回归分析显示，头痛在女性，并发的精神病，IBD，CD和UC中更为普遍。年龄，性别分布以及高血压和精神疾病的患病率在各组之间是匹配的，IBD，CD和UC与对照组相比，头痛和偏头痛的患病率仍存在差异。