The term arterial stiffness (ArSt) describes structural changes in arterial wall related to the loss of elasticity and is known as an independent predictor of cardiovascular diseases (CVD). The evidence relating to ArSt and triglycerides (TG) shows contradictory results. This paper means to survey the association between high TG and ArSt, utilizing the cardio-ankle vascular index (CAVI). Subjects aged between 25 and 64 years from a random population-based sample were evaluated between 2013 and 2016. Data from questionnaires, blood pressure, anthropometric measures, and blood samples were collected and analyzed. CAVI was measured using VaSera VS-1500 N devise. Subjects with a history of CVD or chronic renal disease were excluded. One thousand nine hundred thirty-four participants, 44.7% of males, were included. The median age was 48 (Interquartile Range [IQR] 19) years, TG levels were 1.05 (0.793) mmol/L, and CAVI 7.24 (1.43) points. Prevalence of high CAVI was 10.0% (14.5% in males and 6.4% in females; P < 0.001) and prevalence of hypertriglyceridemia was 20.2% (29.2% in males and 13% in females, P < 0.001). The correlation between TG and CAVI was 0.136 (P < 0.001). High CAVI values were more prevalent among participants with metabolic syndrome (MetS), high blood pressure, dysglycemia, abdominal obesity, high LDL-cholesterol (LDL-c), and high total cholesterol. Using binary regression analysis, high TG were associated with high CAVI, even after adjustment for other MetS components, age, gender, smoking status, LDL-c, and statin treatment (β = 0.474, OR = 1.607, 95% CI = 1.063–2.429, P = 0.024). TG levels were correlated with ArSt, measured as CAVI. High TG was associated with high CAVI independent of multiple cardiometabolic risk factors. Awareness of the risks and targeted treatment of hypertriglyceridemia could further benefit in reducing the prevalence of CVD and events.

中文翻译：

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基于人群的样本中高甘油三酯与动脉僵硬度之间的关联：Kardiovize Brno 2030 研究。

术语动脉僵硬度 (ArSt) 描述了与弹性丧失相关的动脉壁结构变化，被称为心血管疾病 (CVD) 的独立预测因子。有关 ArSt 和甘油三酯 (TG) 的证据显示出相互矛盾的结果。本文旨在利用心踝血管指数 (CAVI) 调查高 TG 与 ArSt 之间的关联。在 2013 年至 2016 年期间，对来自基于人群的随机样本中年龄在 25 至 64 岁之间的受试者进行了评估。收集并分析了来自问卷、血压、人体测量指标和血液样本的数据。使用 VaSera VS-1500 N 装置测量 CAVI。排除有 CVD 或慢性肾病病史的受试者。包括 1934 名参与者，其中男性占 44.7%。中位年龄为 48 岁（四分位距 [IQR] 19），TG 水平为 1.05 (0.793) mmol/L，CAVI 为 7.24 (1.43) 分。高 CAVI 的患病率为 10.0%（男性为 14.5%，女性为 6.4%；P < 0.001），高甘油三酯血症的患病率为 20.2%（男性为 29.2%，女性为 13%，P < 0.001）。TG 与 CAVI 的相关性为 0.136（P < 0.001）。高 CAVI 值在患有代谢综合征 (MetS)、高血压、血糖异常、腹部肥胖、高低密度脂蛋白胆固醇 (LDL-c) 和高总胆固醇的参与者中更为普遍。使用二元回归分析，高 TG 与高 CAVI 相关，即使在调整其他 MetS 成分、年龄、性别、吸烟状况、LDL-c 和他汀类药物治疗后也是如此（β = 0.474，OR = 1.607，95% CI = 1.063– 2.429，P = 0.024）。TG 水平与 ArSt 相关，测量为 CAVI。高 TG 与独立于多种心脏代谢危险因素的高 CAVI 相关。对高甘油三酯血症的风险的认识和有针对性的治疗可以进一步有益于降低 CVD 和事件的患病率。