We identify factors associated with the normalization of the CD4+:CD8+ T cell ratio among UK Collaborative HIV Cohort study participants, and describe the association of the CD4+ and CD8+ T cell counts and the CD4+:CD8+ T cell ratio, with the risk of new AIDS events among individuals who achieve a suppressed viral load. Participants initiating combination antiretroviral therapy (cART) after 2006 with a CD4+:CD8+ T cell ratio <1, and viral suppression within 6 months were included. Cox proportional hazard models were used to examine associations with ratio normalization (ratio ≥1). Poisson regression models were used to investigate factors associated with the development of AIDS after viral load suppression. A total of 13,178 participants [median age: 37 (interquartile range: 31–44)] were followed for 75,336 person-years. Of the 4,042 (32.9%) who experienced ratio normalization, individuals with a high CD4+ T cell count [>500 vs. ≤200 cells/mm³, adjusted hazard ratio (95% confidence interval): 7.93 (6.97–9.01)], low CD8+ T cell count [>1,150 vs. ≤500 cells/mm³: 0.18 (0.16–0.21)], and low CD4+:CD8+ T cell ratio [>0.8 vs. <0.2: 12.36 (10.41–14.68)] at cART initiation were more likely to experience ratio normalization. Four hundred and nineteen people developed a new AIDS event. Most recent CD4+ T cell count [>500 vs. ≤200 cells/mm³: adjusted rate ratio 0.24 (0.16–0.34)] and CD4+:CD8+ T cell ratio [>0.8 vs. <0.2: 0.33 (0.21–0.52)] were independently associated with a new AIDS event. One third of study participants experienced ratio normalization after starting cART. CD4+ T cell count and CD4+:CD8+ T cell ratio are both individually associated with ratio normalization and the development of new AIDS events after cART.

中文翻译：

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CD4+:CD8+ T 细胞比率正常化和 HIV 感染者开始抗逆转录病毒治疗后发生 AIDS 事件。

我们确定了与英国合作 HIV 队列研究参与者中 CD4+:CD8+ T 细胞比率正常化相关的因素，并描述了 CD4+ 和 CD8+ T 细胞计数以及 CD4+:CD8+ T 细胞比率与新发艾滋病风险的关联病毒载量受到抑制的个体之间发生的事件。2006 年后开始联合抗逆转录病毒治疗 (cART) 且 CD4+:CD8+ T 细胞比率 <1 并且在 6 个月内进行病毒抑制的参与者被包括在内。Cox 比例风险模型用于检查与比率归一化（比率≥1）的关联。使用泊松回归模型研究病毒载量抑制后与艾滋病发展相关的因素。共有 13,178 名参与者 [中位年龄：37（四分位距：31-44）] 被跟踪了 75,336 人年。在 4,042 (32.³、调整后的风险比（95% 置信区间）：7.93 (6.97–9.01)]，低 CD8+ T 细胞计数 [>1,150 vs. ≤500 个细胞/mm ³ : 0.18 (0.16–0.21)]，以及低 CD4+:CD8+在 cART 启动时，T 细胞比率 [>0.8 vs. <0.2: 12.36 (10.41–14.68)] 更有可能经历比率正常化。419 人开发了一个新的 AIDS 事件。最近的 CD4+ T 细胞计数 [>500 vs. ≤200 个细胞/mm ³：调整率比率 0.24 (0.16–0.34)] 和 CD4+:CD8+ T 细胞比率 [>0.8 vs. <0.2: 0.33 (0.21–0.52)] 与新的 AIDS 事件独立相关。三分之一的研究参与者在开始 cART 后经历了比率正常化。CD4+ T 细胞计数和 CD4+:CD8+ T 细胞比率均与比率正常化和 cART 后新 AIDS 事件的发展相关。