Ascariasis is a neglected tropical disease, caused by Ascaris lumbricoides, affecting 800 million people worldwide. Studies focused on the early stage of parasite infection, occurring in the gut, liver and lungs, require the use of a mouse model. In these models, the porcine ascarid, Ascaris suum, is often used. The results obtained from these studies are then used to draw conclusions about A. lumbricoides infections in humans. In the present study, we sought to compare larval migration of A. suum and A. lumbricoides in mouse models. We used a previously developed mouse model of ascariasis, which consists of two mouse strains, where one mouse strain – C57BL/6J – is a model for relative susceptibility and the other – CBA/Ca – for relative resistance. Mice of both strains were infected with either A. suum or A. lumbricoides. The larval burden was assessed in two key organs, the liver and lungs, starting at 6 h post infection (p.i.) and ending on day 8 p.i. Additionally, we measured the larval size of each species (μm) at days 6, 7 and 8 p.i. in the lungs. We found that larval burden in the liver is significantly higher for A. lumbricoides than for A. suum. However, the inverse is true in the lungs. Additionally, our results showed a reduced larval size for A. lumbricoides compared to A. suum.

c虫病是一种被忽视的热带病，由A虫（Ascaris lumbricoides）引起，影响了全世界8亿人。研究集中在肠道，肝脏和肺部的寄生虫感染的早期阶段，需要使用小鼠模型。在这些模型中，经常使用猪a虫，即猪scar虫。从这些研究中获得的结果随后可用于得出有关人中A. lumbricoides感染的结论。在本研究中，我们试图比较A. suum和lumbricoides的幼虫迁移在鼠标模型中。我们使用了先前开发的as虫病小鼠模型，该模型由两种小鼠品系组成，其中一种小鼠品系-C57BL / 6J-是相对易感性的模型，另一种是CBA / Ca-相对抗性的模型。两种菌株的小鼠均感染了A. suum或A. lumbricoides。在感染后（pi）的6小时开始并在pi的第8天结束时，评估了两个关键器官（肝脏和肺）的幼虫负担。此外，我们在第6、7和8天测量了每种物种的幼虫大小（μm）。 pi在肺部。我们发现在肝脏是幼虫负担显著较高的是蛔虫比A.猪蛔虫。但是，在肺中则相反。此外，我们的研究结果表明为降低幼虫大小蛔虫相比A.猪蛔虫。