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Therapeutic efficacy of a newly synthesized benzimidazole compound BTP-OH against murine schistosomiasis mansoni
Journal of Helminthology ( IF 1.6 ) Pub Date : 2020-07-15 , DOI: 10.1017/s0022149x20000541
A Taman 1 , B Mansour 2 , M Y Youssef 3 , S M Alhusseiny 1
Affiliation  

Because of the increasingly emerging praziquantel resistance, there is a crucial need to develop new anti-schistosomal agents. This work was conducted to assess the therapeutic efficacy of a new benzimidazole compound (BTP-OH) in mice experimentally infected with Schistosoma mansoni. A total of 40 Swiss albino female mice were divided into an infected untreated group and three infected treated groups (using praziquantel and BTP-OH). The compound activity was evaluated through parasitological, histopathological and scanning electron microscopy studies. Praziquantel and BTP-OH at both doses significantly reduced male (75%, 42.67% and 61.08%, respectively), female (71.45%, 48.94% and 68.13%, respectively) and total worm burden (75.21%, 42.42% and 62.28%, respectively), as well as tissue egg load in the liver (71.22%, 42.12% and 66.04%, respectively). In oogram, praziquantel significantly increased the percentage of dead eggs (65.89%), while BTP-OH significantly reduced the percentage of immature eggs (30.43% and 19.64%). BTP-OH significantly diminished granuloma count (33.87% and 44.77%) and diameter (39.23% and 49.40%), and caused ultrastructural changes in the tegument of adult schistosomes. This study provides evidence for the schistosomicidal efficacy of BTP-OH. However, future studies are needed to elucidate the full mechanisms of action and effects of BTP-OH on other human schistosomes.

中文翻译:

新合成的苯并咪唑类化合物BTP-OH对鼠曼氏血吸虫病的治疗效果

由于日益出现的吡喹酮耐药性,迫切需要开发新的抗血吸虫药物。进行这项工作是为了评估一种新的苯并咪唑化合物 (BTP-OH) 在实验性感染小鼠中的治疗效果曼氏血吸虫. 总共 40 只瑞士白化病雌性小鼠被分为一个感染的未治疗组和三个感染的治疗组(使用吡喹酮和 BTP-OH)。通过寄生虫学、组织病理学和扫描电子显微镜研究评估了化合物的活性。两种剂量的吡喹酮和 BTP-OH 均显着降低了男性(分别为 75%、42.67% 和 61.08%)、女性(分别为 71.45%、48.94% 和 68.13%)和总蠕虫负担(75.21%、42.42% 和 62.28%) ,分别),以及肝脏中的组织卵负荷(分别为 71.22%、42.12% 和 66.04%)。在oogram中,吡喹酮显着增加了死卵的百分比(65.89%),而BTP-OH显着降低了未成熟卵的百分比(30.43%和19.64%)。BTP-OH 显着减少肉芽肿计数(33.87% 和 44.77%)和直径(39.23% 和 49.40%),并引起成虫外皮的超微结构变化。该研究为 BTP-OH 的血吸虫杀灭功效提供了证据。然而,需要未来的研究来阐明 BTP-OH 对其他人类血吸虫的全部作用机制和影响。
更新日期:2020-07-15
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