ABSTRACT

Bavachinin is a flavanone obtained from the Chinese herb, Fructus Psoraleae. Flavonoids and flavanones are recognized as cancer preventive agents. We investigated the anticancer properties of bavachinin using a model of dimethylhydrazine (DMH and dextran sodium sulfate (DSS) induced rat colon cancer. We investigated aberrant crypt foci (ACF), hyperplastic lesions, catalase (CAT), superoxide dismutase (SOD) and glutathione (GST) levels in Wistar rats. Expression of cancer biomarkers including IL-6, p53, Bcl2 and BAX was investigated. We found that bavachinin administered to rats re-established the colonic crypts that were damaged by DMH and prevented progression of the cancer.

摘要

Bavachinin 是一种从中草药补骨脂中提取的黄烷酮。类黄酮和黄烷酮被认为是癌症预防剂。我们使用二甲基肼（DMH 和葡聚糖硫酸钠 (DSS) 诱导的大鼠结肠癌）模型研究了 bavachinin 的抗癌特性。我们研究了异常隐窝病灶 (ACF)、增生性病变、过氧化氢酶 (CAT)、超氧化物歧化酶 (SOD) 和谷胱甘肽Wistar 大鼠中的 (GST) 水平。研究了包括 IL-6、p53、Bcl2 和 BAX 在内的癌症生物标志物的表达。我们发现，给大鼠施用巴瓦金宁可重建被 DMH 损坏的结肠隐窝，并阻止癌症的进展。