Recent evidences suggest a protective mechanism of vitamin D signaling against breast cancer by the autocrine/paracrine manner and may modestly reduce the risk of breast cancer. Despite lots of sunshine, vitamin D deficiency is widespread in India. Moreover, there are limited studies from Indian population regarding circulatory 25(OH) D and breast cancer risk. Thus, the aim of the present study is to investigate circulatory 25(OH) D in relation to breast cancer risk and its association with various clinico-pathological parameters from Indian population. Total 297 subjects, comprising of 157 controls and 140 breast cancer patients were enrolled for the study. Circulatory 25(OH) D was analyzed by HPLC. Statistical analysis was carried out by SPSS software version 15. Further, subjects were categorized into severe, moderate, mild vitamin D deficiency and sufficiency. The prevalence of severe and moderate 25(OH) D deficiency was higher in breast cancer patients as compared to controls. Mean values of 25(OH) D were lower in breast cancer patients as compared to controls in mild, moderate and severe deficient groups (p = 0.07, p = 0.003 and p = 0.001). Moreover, 25(OH) D was significantly lower in postmenopausal breast cancer patients as compared to premenopausal breast cancer patients, particularly in severe deficient group. The levels of 25(OH) D were lower in ER and PR negative receptor status as compared to the positive receptor in severe deficient category (p = 0.06 and p = 0.09 respectively). Whereas, the mean values of 25(OH) D were lower in HER 2 negative receptor status as compared to positive receptor status in the moderate deficient category (p = 0.09). Further, severe deficient group showed significantly lower levels of 25(OH) Din TNBC as compared to luminal A subtype (p = 0.01). Thus, Results indicate that 25(OH) D deficiency might be associated with increased risk of breast cancer. Moreover, severe 25(OH) D deficiency is associated with aggressive behavior of breast cancer.

最近的证据表明，维生素D信号通过自分泌/旁分泌方式对乳腺癌具有保护作用，并且可以适度降低乳腺癌的发病风险。尽管阳光充足，但维生素D缺乏症在印度仍很普遍。此外，印度人关于循环25（OH）D和乳腺癌风险的研究有限。因此，本研究的目的是研究与乳腺癌风险有关的循环25（OH）D及其与印度人群各种临床病理参数的关系。该研究共纳入297位受试者，包括157位对照和140位乳腺癌患者。通过HPLC分析循环的25（OH）D。使用SPSS 15版软件进行统计分析。此外，将受试者分为严重，中度，轻度维生素D缺乏和充足。与对照组相比，乳腺癌患者中重度和中度25（OH）D缺乏症的患病率更高。与轻度，中度和重度缺陷组的对照组相比，乳腺癌患者的25（OH）D平均值较低（p = 0.07，p = 0.003和p = 0.001）。此外，与绝经前乳腺癌患者相比，绝经后乳腺癌患者的25（OH）D明显降低，特别是在严重缺乏者中。ER和PR阴性受体状态的25（OH）D水平低于严重缺乏症患者的阳性受体水平（分别为p = 0.06和p = 0.09）。相比之下，HER 2阴性受体状态的25（OH）D平均值低于中度缺陷类别的阳性受体状态（p = 0.09）。此外，与管腔A亚型相比，严重缺陷组的TNBC中25（OH）D的水平显着降低（p = 0.01）。因此，结果表明25（OH）D缺乏可能与乳腺癌风险增加有关。此外，严重的25（OH）D缺乏症与乳腺癌的攻击行为有关。