The prominent success of polycaprolactone (PCL) electrospun nanofibrous mats (ENM) has expanded the use of PCL over other polymers for tissue engineering applications. However, the major challenge in the design of a nanofibrous scaffold is to modify its surface properties while preserving its bulk properties. Therefore, the first part of the study is focused on the fabrication of PCL-ENMs by alternating-current electrospinning using the following solvent systems: formic acid, formic acid/acetic acid (1/1) and formic acid/acetic acid/acetone (1/1/1). While the second part is focused on an nm-thick surface chemical modification via medium pressure argon and nitrogen plasma treatment, and the third part is dedicated to investigating the morphology, wettability, surface functional groups, crystallite size, crystallinity, crystallization, and melting temperature of plasma-treated nanofibers. Samples were characterized using scanning electron microscopy (SEM), water contact angle analysis (WCA), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC). WCA and SEM results showed that plasma treatments significantly improve the wettability of the PCL ENMs without compromising their surface morphology. XPS analysis revealed that argon and nitrogen gases are responsible for a substantial increase in polar oxygen and nitrogen functional groups respectively. Out of the six plasma-treated PCL ENMs understudy, the argon plasma-treated sample showed superior hydrophilicity (from 136° to ~35°) followed by nitrogen plasma treatment (from 136° to ~42°). It was also found from XRD that the crystallite size was not significantly affected by the conducted plasma treatments. Moreover, the degree of crystallinity was also not altered by the plasma treatments, as was observed by DSC and FTIR. The conducted experiments showed that the surface properties of the PCL ENMs could be positively affected while maintaining their beneficial bulk properties thereby making these plasma-modified ENMs excellent candidates in multiple biomedical and tissue engineering applications.

聚己内酯（PCL）电纺纳米纤维毡（ENM）的显著成功使PCL的用途扩展到了组织工程应用中的其他聚合物之上。然而，设计纳米纤维支架的主要挑战是在保留其整体性能的同时改变其表面性能。因此，研究的第一部分着重于使用以下溶剂系统通过交流电纺丝法制造PCL-ENM：甲酸，甲酸/乙酸（1/1）和甲酸/乙酸/丙酮（ 1/1/1）。第二部分着重于通过中压氩气和氮气等离子体处理的纳米级表面化学改性，第三部分则致力于研究形态，润湿性，表面官能团，微晶尺寸，结晶度，结晶度，和等离子体处理的纳米纤维的熔融温度。使用扫描电子显微镜（SEM），水接触角分析（WCA），X射线光电子能谱（XPS），X射线衍射（XRD），傅里叶变换红外光谱（FT-IR）和差示扫描来表征样品量热法（DSC）。WCA和SEM结果表明，等离子体处理可显着提高PCL ENM的润湿性，而不会损害其表面形态。XPS分析表明，氩气和氮气分别导致极性氧和氮官能团的大量增加。在六个经过等离子体处理的PCL ENM中，经氩气等离子体处理的样品显示出优越的亲水性（从136°至〜35°），随后进行了氮等离子体处理（从136°至〜42°）。从XRD还发现，进行的等离子体处理没有显着影响微晶尺寸。而且，如通过DSC和FTIR观察到的，通过等离子体处理也没有改变结晶度。进行的实验表明，PCL ENM的表面性能可以受到积极影响，同时保持其有益的整体性能，从而使这些血浆修饰的ENM在多种生物医学和组织工程应用中成为优秀的候选者。