Using non-integrative reprogramming method, a human induced pluripotent stem cell (iPSC) line, ZZUNEUi005-A, was generated from a 36-year-old male patient with Wilson’s disease, carrying a homozygous Pro992Leu mutation in the ATP7B gene. This cell line shows pluripotency both in vitro and in vivo and has a normal karyotype. Furthermore, we showed that this iPSC line could be differentiated into neural and hepatocyte-like cells.

中文翻译：

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从具有ATP7B基因纯合Pro992Leu突变的威尔逊病患者中产生无整合诱导多能干细胞（iPSC）系（ZZUNEUi005-A）。

使用非整合重编程方法，从一名威尔逊氏病的36岁男性患者中产生了人类诱导的多能干细胞（iPSC）系ZZUNEUi005-A，该患者在ATP7B基因中携带纯合Pro992Leu突变。该细胞系在体外和体内均显示多能性，并具有正常的核型。此外，我们表明，该iPSC系可以分化为神经细胞和肝细胞样细胞。