Abstract Age at first lambing and lambing interval are two important reproductive traits affecting the longevity of sheep as well as the production yield in the lifetime. Thus, to identify the genomic regions associated with these traits, a genome-wide association study (GWAS) was performed in Baluchi sheep by using the Illumina Ovine SNP50 K chip. The GWAS analysis was conducted in the fixed linear model by PLINK software. The results of the present study detected, for the first time, two novel SNPs on chromosomes 10 and 15 significantly associated with age at first lambing and lambing interval, respectively. These SNPs were located within ovine genes including FAM155A and SYT13, known to be involved in the immune responses. Our findings may provide new perspectives to identify genomic regions underlying reproductive traits in sheep.

中文翻译：

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使用 50K SNP 芯片鉴定影响绵羊产羔性状的两种新型 SNP

摘要 初产龄和产羔间隔是影响绵羊寿命和产量的两个重要繁殖性状。因此，为了鉴定与这些性状相关的基因组区域，使用 Illumina Ovine SNP50 K 芯片在俾路支绵羊中进行了全基因组关联研究 (GWAS)。GWAS 分析是通过 PLINK 软件在固定线性模型中进行的。本研究的结果首次在 10 号和 15 号染色体上检测到两个新的 SNP，分别与第一次产羔和产羔间隔的年龄显着相关。这些 SNP 位于绵羊基因中，包括 FAM155A 和 SYT13，已知参与免疫反应。我们的发现可能为鉴定绵羊生殖特征的基因组区域提供新的视角。