ZnO nanoparticles (ZnO-NPs) can be used as nano medicine for Staphylococcus aureus infection, which causes deleterious effects on liver, kidney and lung tissue, as it causes catarrhal bronchitis, peri-bronchial oedema, lymphocytic granulomas, oedematous fluid and haemorrhage inside the bronchi, and interstitial pneumonia. In this research ZnO nanoparticle (ZnO-NPs) synthesis by biogenic method using green alga Ulva fasciata and by wet chemical method. Both of them tested in vitro and in vivo against Staphylococcus aureus. The characterization of ZnO-NPs was detected by U.V spectroscopy, Fourier-transform infrared (FTIR), Energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). In vivo assessment eight groups, each group contain of five rats and the treatment as follow (1) an uninfected control group; (2) an infected group; groups (3), (4), and (5) were injected with biogenic or chemical ZnO-NPs or zinc acetate, as the bulk group, respectively; and groups (6), (7) and (8) were infected and then treated in the same manner as groups (3), (4), and (5), respectively. The blood profile, biochemical parameters, phagocytic activity and histological assessment of liver, kidney and lung tissue of each rat was investigated after 20 days. The rats treated with 5 mg/1 kg natural ZnO-NPs showed improved lung characteristics, and the number of platelets in the infected groups treated with ZnO-NPs from chemical and natural sources (G6 and G7) was close to those in the control group. However, the trend was reversed for regarding lymphocytes, which remained at higher levels in uninfected animals treated with synthetic ZnO-NPs (G4) than in infected rats treated with synthetic ZnO-NPs (G7). Moreover, a significant difference in phagocytic activity was found among all groups compared to that of controls. Compared to control group rats (G1), uninfected rats injected with only natural ZnO-NPs (G3) showed a significant (P < 0.05) improvement in the phagocytic index. We propose that ZnO-NPs produced from natural sources are preferable to those produced from chemical sources for use as nano medicine for the treatment of S. aureus infection in albino rats.

ZnO纳米颗粒（ZnO-NPs）可以用作金黄色葡萄球菌感染的纳米药物，它对肝，肾和肺组织产生有害作用，因为它会引起卡他性支气管炎，支气管周水肿，淋巴细胞性肉芽肿，水肿液和出血。支气管和间质性肺炎。在这项研究中，ZnO纳米颗粒（ZnO-NPs）通过使用绿藻Ulva fasciata的生物生成方法和湿化学方法合成。他们都在体外和体内测试了金黄色葡萄球菌。ZnO-NPs的表征通过紫外光谱，傅立叶变换红外（FTIR），能量色散X射线光谱（EDX）进行检测，X射线衍射（XRD），扫描电子显微镜（SEM）和透射电子显微镜（TEM）。体内评估八组，每组包含五只大鼠，治疗方法如下：（1）未感染对照组。（二）感染人群；（3），（4）和（5）组分别注入生物或化学ZnO-NP或乙酸锌作为主体。（6），（7）和（8）组被感染，然后分别以与（3），（4）和（5）组相同的方式进行治疗。20天后检查每只大鼠的血液概况，生化参数，吞噬活性和肝，肾和肺组织的组织学评估。用5 mg / 1 kg天然ZnO-NPs处理的大鼠表现出改善的肺部特性，用化学和天然来源（G6和G7）的ZnO-NPs处理的感染组中的血小板数量与对照组接近。 。但是，关于淋巴细胞的趋势却相反，与未使用合成ZnO-NPs（G7）处理的受感染大鼠相比，在使用合成ZnO-NPs（G4）处理的未感染动物中其水平仍较高。此外，与对照组相比，所有组之间的吞噬活性均存在显着差异。与对照组大鼠（G1）相比，仅注射天然ZnO-NP（G3）的未感染大鼠的吞噬指数显着提高（P <0.05）。我们建议，由自然来源生产的ZnO-NP比由化学来源生产的ZnO-NP更好，可作为纳米药物来治疗糖尿病。与对照组大鼠（G1）相比，仅注射天然ZnO-NP（G3）的未感染大鼠的吞噬指数显着提高（P <0.05）。我们建议，从自然来源生产的ZnO-NP比从化学来源生产的ZnO-NP更好，用作纳米药物来治疗糖尿病。与对照组大鼠（G1）相比，仅注射天然ZnO-NP（G3）的未感染大鼠的吞噬指数显着提高（P <0.05）。我们建议，由自然来源生产的ZnO-NP比由化学来源生产的ZnO-NP更好，可作为纳米药物来治疗糖尿病。白化病大鼠中的金黄色葡萄球菌感染。