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How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases.
Clinical Immunology ( IF 8.6 ) Pub Date : 2020-07-15 , DOI: 10.1016/j.clim.2020.108538
N M Ter Haar 1 , M H A Jansen 2 , J F Frenkel 2 , S J Vastert 1
Affiliation  

IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.



中文翻译:

自发性炎症如何转变为自体免疫性炎症:来自单基因和复杂的IL-1介导的自发性炎症疾病的见解。

IL-1介导的自身炎症性疾病的特征是无法解释的发烧,全身性和局部性炎症。特征性症状主要是由于先天免疫途径的过度激活引起的。然而,在一些典型的由IL-1介导的疾病患者中,慢性疾病表现是在没有急性炎症的情况下发展的,这提示了适应性免疫途径的参与。我们讨论了先天性免疫途径的慢性激活如何导致自身炎性疾病患者自身免疫疾病特征的临床观察以及新颖见解,以及我们如何需要更好地理解这些后遗症以改善治疗策略。

更新日期:2020-07-28
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