The molecule computation based on the Boolean logic gates holds great promising in chemical detection, biomarker imaging and disease diagnosis. However, the design of advanced logic gates based on novel nanoplatform of fluorescent-customizable MOFs (metal-organic frameworks) is still in infancy. Herein, whole-visible-spectra fluorescent nanoMOFs are successfully applied to build such a new-generation data processor. Luminescent MOFs (LMOFs) integrated with three functional dyes as DPA, 5-AF and TCPP are synthesized with an in situ one-pot strategy with an ultra-large Stokes shift of 290 nm, in which the dyes undertake multiple roles as modulators, fluorophores, FRET (fluorescence resonance energy transfer) transmitters as well as signal reporters. LMOFs with expected colors can be customized through our established color database, and a model of LMOFs-based barcodes is established to demonstrate the excellent capability of information storage. Through the control of chemical signals as inputs, the elaborated nanoMOFs platform can well implement basic INHIBIT gate, complicated half-adder and a multi-input multi-output (MIMO) logic circuit. Additionally, such MIMO logic circuit is exemplified to assist in the diagnosis of various diseases by taking different disease-related signal species (¹O₂, ClO⁻ (LOD = 0.3 μM) and Cu²⁺ (LOD = 2.3 μM)) as input signals, prefiguring the broad application prospects of the developed fluorescent-customizable nanoMOFs in life sciences.

基于布尔逻辑门的分子计算在化学检测，生物标志物成像和疾病诊断中具有广阔的前景。但是，基于新型的荧光可定制MOF（金属有机框架）纳米平台的高级逻辑门的设计仍处于起步阶段。在此，全可见光谱荧光纳米MOF已成功应用于构建这样的新一代数据处理器。集成了三种功能性染料（如DPA，5-AF和TCPP）的发光MOF（LMOF），采用原位一锅法，具有290 nm的超大Stokes位移，在该染料中，作为调节剂，荧光团发挥多种作用，FRET（荧光共振能量转移）发射器以及信号报告器。具有预期颜色的LMOF可以通过我们建立的颜色数据库进行自定义，建立了基于LMOF的条形码模型，以证明其优异的信息存储能力。通过控制化学信号作为输入，精心设计的nanoMOF平台可以很好地实现基本的INHIBIT门，复杂的半加法器和多输入多输出（MIMO）逻辑电路。另外，示例了这种MIMO逻辑电路，通过获取与疾病相关的不同信号种类来辅助诊断各种疾病（¹ Ò ₂，CLO ^-（LOD = 0.3μM）和Cu ²⁺（LOD = 2.3μM））作为输入信号，在预告着生命科学的发达荧光定制nanoMOFs的广阔的应用前景。