The ethno-pharmaceutical use of the edible fixed oil produced from lentisk (Pistacia lentiscus) berries covers a long tradition in several Mediterranean regions. Many of the health-promoting properties of lentisk berry oil (LBO) have been associated with the content of polar (poly)phenolic compounds. However, the polar fraction (methanol 80%, v/v) of LBO (LBO-pf) remains poorly and inadequately characterized. We assessed the phytochemical composition (fatty acids, phytosterols and polyphenols) of cold-pressed LBO produced in Cilento (Campania region, Italy) over four years of production (2015–2018). Main phenolic compounds present in LBO-pf were identified and semi-quantified combining ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) and HPLC with diode array detection. Phenolic compounds, also responsible for oil stability and antioxidant properties, are relatively abundant in LBO, compared to other edible oils. LBO-pf induced clear dose-dependent effects on the growth of HT-29 cell line derived from human colorectal adenocarcinoma, as evidenced by the cell cycle arrest. Our data support the health-promoting properties of cold-pressed LBO, which is obtained with good yield from spontaneous plants growing in semiarid regions.

中文翻译：

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植物化学特征及其对 Lentisk (Pistacia lentiscus) 浆果油细胞增殖的影响：酚类物质的重估来源

由扁豆 (Pistacia lentiscus) 浆果生产的食用固定油的民族药用用途在几个地中海地区有着悠久的传统。扁豆浆果油 (LBO) 的许多促进健康的特性与极性（多）酚类化合物的含量有关。然而，LBO (LBO-pf) 的极性部分（甲醇 80%，v/v）仍然很差且未充分表征。我们评估了在 Cilento（意大利坎帕尼亚地区）生产的四年（2015-2018 年）冷榨 LBO 的植物化学成分（脂肪酸、植物甾醇和多酚）。LBO-pf 中存在的主要酚类化合物结合超高效液相色谱-电喷雾电离-串联质谱 (UHPLC-ESI-MS/MS) 和 HPLC 与二极管阵列检测相结合进行了鉴定和半定量。与其他食用油相比，酚类化合物在 LBO 中也相对丰富，它也负责油的稳定性和抗氧化性能。正如细胞周期停滞所证明的那样，LBO-pf 对源自人结肠直肠腺癌的 HT-29 细胞系的生长产生明显的剂量依赖性影响。我们的数据支持冷压 LBO 的健康促进特性，这是从生长在半干旱地区的自发植物中获得的高产。