Although papillary endothelial hyperplasia may occur at almost any site, one of the most common sites is the hand. It is generally regarded as a reactive vascular proliferation i.e. exuberant form of organizing thrombus. Diagnosis of Masson tumor can be challenging due to its close clinical, radiological and even histopathological resemblance to angiosarcoma. We present seven cases of Masson tumor of the hand; wanting to reveal its nature using new vascular markers and discuss the treatment options and expected outcomes, present clinical and radiological features that may aid diagnosis and also offer treatment plans. A multicenter retrospective study was performed between January 2014 and November 2019. Immunohistochemical stains of Glut1, WT1, ERG, CD31 and alpha smooth muscle actin (ASMA) were performed on each cases. We found seven cases during the examined period. 4 out of 7 cases were women. All lesions occurred in the hands. 3 out of 7 cases appeared in a previously present vascular malformation. All cases were treated with surgical excision and the diagnosis of papillary endothelial hyperplasia was made by histology. Pre-operative testing (radiograph/MRI/US/fine needle aspiration biopsy) did not suggest the diagnosis of Masson tumor; however, aspiration cytology could rule out malignancy. The proliferative endothelial cells proved to be Glut1 negative and WT1 positive and the accompanying pericytic cells were ASMA positive in all cases. Though Masson tumor is a rare vascular lesion in the hand among other vascular tumors, it should be considered in the differential diagnostics even in the case of previously existing vascular malformation. WT1 positivity of the endothelial cells and the accompanying pericytic cells raises the question whether the initially reactive endothelial proliferation may transform into a true benign vascular tumor.

尽管乳头状血管内皮增生几乎可以发生在任何部位，但最常见的部位之一是手。通常认为它是反应性血管增生，即组织血栓的旺盛形式。由于Masson肿瘤与血管肉瘤的临床，放射学甚至组织病理学相似，因此其诊断可能具有挑战性。我们提出了7例手部马森瘤；希望使用新的血管标记物揭示其性质并讨论治疗方案和预期结果，介绍可能有助于诊断的临床和放射学特征，并提供治疗计划。在2014年1月至2019年11月之间进行了一项多中心回顾性研究。每例病例均进行了Glut1，WT1，ERG，CD31和α平滑肌肌动蛋白（ASMA）的免疫组织化学染色。在审查期间，我们发现了7个案例。7例中有4例是女性。所有病变都发生在手中。7例中有3例出现了先前存在的血管畸形。所有病例均经手术切除，并通过组织学诊断为乳头状内皮增生。术前检查（放射线照相/ MRI / US /细针穿刺活检）未提示诊断为马森肿瘤。但是，抽吸细胞学检查可以排除恶性肿瘤。在所有情况下，增殖的内皮细胞均被证实为Glut1阴性和WT1阳性，而伴随的周细胞为ASMA阳性。尽管Masson肿瘤是其他血管瘤中手部罕见的血管病变，但即使在先前存在的血管畸形的情况下，也应在鉴别诊断中予以考虑。