Purpose

The purpose of the current study was to evaluate thyroid function in terms of serum thyroid-stimulating hormone (TSH, also known as thyrotropin), 3,5,3′-triiodo-l-thyronine (T3), and 3,5,3′,5′-tetraiodo-l-thyronine (T4, also known as thyroxine) levels in migraineurs in comparison with non-migraineurs using a systematic review of literature and a meta-analysis.

Methods

This is a systematic review of case-control studies on serum TSH, T3, and T4 concentrations of migraineurs in comparison with non-migraineurs. After extracting the data from the finally included studies, the weighted overall standardized mean difference (SMD) was calculated.

Results

The weighted overall SMD for the impact of TSH, T3, and T4 blood levels for migraineurs in comparison with non-migraineurs was as follows: 0.804 (95% CI, 0.045–1.564), − 0.267 (95% CI, − 0.660–0.125), 0.093 (95% CI, − 0.077–0.263), respectively. It is noteworthy that only the p value for the significance of the overall SMD for serum TSH level was statistically significant (p = 0.038), as examined by the z-test.

Conclusions

The results of the current study point to an association between migraine pathogenesis and changing TSH levels in comparison with those of controls.

中文翻译：

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对最近报告与偏头痛患者甲状腺功能相关的激素水平的研究的系统回顾和荟萃分析，直到 2020 年 4 月。

目的

本研究的目的是通过血清促甲状腺激素（TSH，也称为促甲状腺激素）、3,5,3'-三碘-l-甲状腺氨酸 (T3) 和 3,5,3 ',5'-四碘-l-甲状腺氨酸（T4，也称为甲状腺素）水平在偏头痛患者与非偏头痛患者的比较中使用文献系统回顾和荟萃分析。

方法

这是对偏头痛患者与非偏头痛患者血清 TSH、T3 和 T4 浓度的病例对照研究的系统评价。从最终纳入的研究中提取数据后，计算加权总体标准化平均差（SMD）。

结果

与非偏头痛患者相比，偏头痛患者 TSH、T3 和 T4 血液水平影响的加权总体 SMD 如下：0.804（95% CI，0.045–1.564），- 0.267（95% CI，- 0.660-0.125 ), 0.093 (95% CI, − 0.077–0.263)，分别。值得注意的是，通过z检验，只有总体 SMD 对血清 TSH 水平的显着性的p值具有统计学意义（p = 0.038）。

结论

当前研究的结果表明，与对照组相比，偏头痛发病机制与 TSH 水平变化之间存在关联。