Urolithiasis is a common disease that affects 5% to 8.8% of the world population with high recurring frequency. Therefore, there is an urgent need for the rapid and efficient diagnostics of urolithiasis. In this study, we developed a quantum dots (QDs)-based sensor for detecting urolithiasis oxalate. Urolithiasis oxalate was quantified by reducing Cu²⁺ to Cu⁺, which can be selectively recognized by CdTe QDs. The homogeneous sensing system shows high sensitivity for oxalate detection in the range of 0.1 μM to 10 mM within 6 min; moreover, the visual detection of 10 μM oxalate could be achieved by the naked eye. Our method was tested on 53 clinical samples; it showed 100% specificity and sensitivity for calcium oxalate urolithiasis compared with clinical diagnosis, even for hematuria samples. Furthermore, this method can be expanded to other wide range of biochemistry applications for medical diagnosis and point-of-care testing.

中文翻译：

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草酸的快速和高度灵敏的视觉检测，通过CdTe量子点的选择性识别反应对尿路结石进行代谢评估。

尿石症是一种常见疾病，复发频率高，影响世界人口的5％至8.8％。因此，迫切需要快速有效地诊断尿石症。在这项研究中，我们开发了一种基于量子点（QDs）的传感器，用于检测尿石症草酸盐。草酸尿石症通过将Cu ²⁺还原为Cu ⁺进行定量，可以被CdTe QD选择性地识别。均质感测系统在6分钟内对草酸盐检测的灵敏度很高，范围为0.1μM至10 mM；此外，肉眼可以目测10μM草酸盐。我们的方法在53个临床样品上进行了测试；与草酸钙尿石症相比，它对临床诊断显示出100％的特异性和敏感性，即使对于血尿样本也是如此。此外，该方法可以扩展到其他广泛的生物化学应用中，用于医学诊断和即时检验。