Mitochondria are the ‘engine’ of cells. Mitochondrial dysfunction is an important mechanism in many human diseases. Many natural products could remedy the mitochondria to alleviate mitochondria-involved diseases. In this review, we summarized the current knowledge of the relationship between the mitochondria and human diseases and the regulation of natural products to the mitochondria. We proposed that the development of mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represents an attractive strategy for a mitochondria-involved disorder therapy. Moreover, investigating the mitochondrial regulation of natural products can potentiate the in-depth comprehension of the mechanism of action of natural products.

中文翻译：

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用天然产物治疗线粒体以治愈人类疾病。

线粒体是细胞的“引擎”。线粒体功能障碍是许多人类疾病的重要机制。许多天然产物可以补救线粒体，以减轻线粒体相关疾病。在这篇综述中，我们总结了线粒体与人类疾病之间的关系以及对线粒体天然产物的调控的当前知识。我们提出线粒体调节剂/营养物质从天然产物到补救线粒体功能障碍的发展代表了涉及线粒体疾病治疗的有吸引力的策略。此外，研究天然产物的线粒体调控可以增强对天然产物作用机理的深入理解。