ABSTRACT

Introduction

Clinicians have waited a long time for a ‘universal’ marker that may help them distinguish infected from non-infected total joint arthroplasties when doubts persist after using classical clinical and biological signs of infection. In recent years, synovial fluid biomarkers including leukocyte esterase, alpha-defensins, and CRP have shown promising results for the diagnosis of periprosthetic joint infections (PJIs).

Areas covered

This review provides an overview of the rational and the use of the Synovasure® alpha-defensin tests in patients with a suspicion of PJI. Using a systematic investigation by keywords, we looked for all citations (and the citations to these citations) of the selected papers.

Expert opinion

The Synovasure® alpha-defensin tests demonstrate high potential for the diagnosis of PJIs. However, the data currently available also show that the universal marker of infection in the settings of PJIs is still to be discovered.

中文翻译：

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用于检测假体周围感染的 Synovasure Alpha Defensin Test 的概况。

摘要

介绍

当使用经典的临床和生物学感染迹象后仍存疑虑时，临床医生一直在等待一种“通用”标记物，该标记物可以帮助他们区分感染性和非感染性全关节置换术。近年来，包括白细胞酯酶、α-防御素和 CRP 在内的滑液生物标志物在假体周围关节感染 (PJI) 的诊断中显示出有希望的结果。

覆盖区域

本综述概述了在怀疑 PJI 的患者中使用 Synovasure® α-防御素测试的合理性和用途。通过关键字系统调查，我们查找了所选论文的所有引用（以及对这些引用的引用）。

专家意见

Synovasure® α-防御素测试显示出诊断 PJI 的巨大潜力。然而，目前可用的数据也表明，PJI 环境中感染的通用标志仍有待发现。