ABSTRACT

Introduction

Penicillin antibiotic allergy labels (AALs) are common and lead to significant negative health and health system outcomes. Direct oral challenge offers a rapid and cost-effective way of removing inaccurate AALs and improving outcomes.

Areas covered

A narrative review (Medline, May 2020) of direct oral challenge in low-risk penicillin allergy in adults is described, and the evidence for the safety and efficacy of this approach in inpatients, outpatients, and special patient groups is presented.

Expert opinion

Whilst the current literature demonstrates the safety and efficacy of direct oral challenge in de-labeling low-risk penicillin allergy in adults, novel approaches are needed to improve access to antibiotic allergy assessment and address the growing global need.

中文翻译：

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取消标签的民主化：对低危青霉素过敏的成年人直接口服挑战的综述。

摘要

介绍

青霉素抗生素过敏标签（AAL）很常见，会导致严重的负面健康和卫生系统后果。直接口头挑战提供了一种快速且经济有效的方式来消除不准确的AAL并改善结果。

覆盖区域

描述了对成人低风险青霉素过敏直接口服挑战的叙述性综述（Medline，2020年5月），并提供了这种方法在住院，门诊和特殊患者组中的安全性和有效性的证据。

专家意见

尽管目前的文献证明了直接口服挑战在成人低风险青霉素过敏标签中的安全性和有效性，但仍需要新颖的方法来改善获得抗生素过敏评估的机会并解决日益增长的全球需求。