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Death of guppy fish (Poecilia reticulata) leukocytes induced by in vivo exposure to temephos and spinosad
International Journal of Environmental Health Research ( IF 3.2 ) Pub Date : 2020-07-14 , DOI: 10.1080/09603123.2020.1791803
K J G Díaz-Resendiz 1, 2 , A T Hermosillo-Escobedo 2 , G H Ventura-Ramón 1 , G A Toledo-Ibarra 1, 2 , D A Girón-Pérez 1 , A Y Bueno-Durán 1 , M I Girón-Pérez 1, 2
Affiliation  

ABSTRACT

Temephos and spinosad are pesticides used for control of vector-borne diseases such as dengue, chikungunya and zika. However, the inadequate use of these substances has affected the health of non-target organisms. The aim of this study was to evaluate and compare, the effects of temephos and spinosad on leukocyte viability and death, using guppy fish (Poecilia reticulate) as a model organism. Guppies were exposed to temephos (10 mg/L) and spinosad (0.5 mg/L) for 7, 14, and 21 days. Afterwards, they were placed in pesticide-free fish tanks (7, 35, and 70 days) for recovery. The results showed that exposure to temephos caused leukocyte death, even at 35 days of recovery. Contrarily, the exposure to spinosad did not cause leukocyte death. This research show, for the first time, that a single dose of temephos causes apoptosis up to 56 days post-exposition, indicating that this pesticide induces chronic effects on immune response cells.



中文翻译:

体内暴露于替美磷和多杀菌素诱导的孔雀鱼 (Poecilia reticulata) 白细胞死亡

摘要

Temephos 和多杀菌素是用于控制媒介传播疾病的杀虫剂,例如登革热、基孔肯雅热和寨卡病毒。然而,这些物质的使用不当已经影响了非靶标生物的健康。本研究的目的是使用孔雀鱼 ( Poecilia reticulate)评估和比较替美磷和多杀菌素对白细胞活力和死亡的影响作为模式生物。孔雀鱼暴露于 temephos (10 mg/L) 和多杀菌素 (0.5 mg/L) 7、14 和 21 天。之后,将它们放入无农药鱼缸(7、35 和 70 天)中进行恢复。结果表明,即使在恢复 35 天后,暴露于 temephos 也会导致白细胞死亡。相反,接触多杀菌素不会导致白细胞死亡。这项研究首次表明,单剂量的 temephos 会导致暴露后长达 56 天的细胞凋亡,这表明这种杀虫剂会对免疫反应细胞产生慢性影响。

更新日期:2020-07-14
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