Frontiers in Molecular Neuroscience ( IF 4.8 ) Pub Date : 2020-06-02 , DOI: 10.3389/fnmol.2020.00113 Viraj Shah 1 , Rahul Mittal 1 , David Shahal 1 , Priyanka Sinha 1 , Erdogan Bulut 1 , Jeenu Mittal 1 , Adrien A Eshraghi 1, 2, 3
Cochlear implants (CIs) are widely used to provide auditory rehabilitation to individuals having severe to profound sensorineural hearing loss (SNHL). However, insertion of electrode leads to inner trauma and activation of inflammatory and apoptotic signaling cascades resulting in loss of residual hearing in implanted individuals. Pharmaceutical interventions that can target these signaling cascades hold great potential for preserving residual hearing by preventing sensory cell damage. Bile salts have shown efficacy in various regions of the body as powerful antioxidants and anti-inflammatory agents. However, their efficacy against inner ear trauma has never been explored. The objective of this study was to determine whether taurodeoxycholic acid (TDCA), a bile salt derivative, can prevent sensory cell damage employing an
中文翻译:
使用电极插入创伤的体外模型评估牛磺脱氧胆酸在提供耳保护作用中的功效。
人工耳蜗(CIs)广泛用于为患有严重至严重的感音神经性听力丧失(SNHL)的个人提供听觉康复。然而,电极的插入导致内部创伤以及炎症和凋亡信号级联反应的激活,导致植入个体的残余听力丧失。可以针对这些信号级联反应的药物干预措施,通过防止感觉细胞损伤,具有保留残余听力的巨大潜力。胆汁盐已在人体的各个部位显示出有效的抗氧化剂和消炎剂功效。然而,它们对内耳外伤的功效从未被探索过。这项研究的目的是确定胆汁盐衍生物牛磺脱氧胆酸(TDCA)是否可以预防感觉细胞损伤。