A series of copolymers composed of methoxy poly(ethylene glycol) and a hydrophobic block of poly(ɛ‐caprolactone‐co‐propargyl carbonate) grafted with poly(2‐[dimethylamino]ethyl methacrylate) was synthesized by combining ring opening polymerization, azide‐alkyne click reaction, and atom transfer radical polymerization (ATRP). Well‐defined copolymers with a target composition and a tailored structure were achieved via the grafting from approach by using a single catalytic system for both click reaction and ATRP. Kinetic studies demonstrated the controlled/living character of the employed polymerization methods. The thermal properties and self‐assembly in aqueous medium of the graft copolymers were dependent on their composition. The resulting polymeric materials showed low cytotoxicity toward L929 cells, demonstrating their potential for biomedical applications. This type of materials containing cationic side chains tethered to biocompatible and biodegradable segments could be the basis for promising candidates as drug and gene delivery systems.

中文翻译：

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将聚（2-甲基丙烯酸二甲基氨基乙酯）接枝到可生物降解的嵌段共聚物上

通过开环聚合，叠氮化物-开环聚合反应合成了一系列由甲氧基聚乙二醇和疏水性嵌段聚（ɛ-己内酯-共-炔丙基碳酸酯）与聚（2-甲基丙烯酸二甲基氨基乙酯）接枝的共聚物。炔烃点击反应和原子转移自由基聚合（ATRP）。通过接枝获得了具有目标组成和定制结构的定义明确的共聚物通过使用单一催化系统同时进行点击反应和ATRP的方法。动力学研究表明所用聚合方法的控制/活性特征。接枝共聚物的热性能和在水性介质中的自组装取决于其组成。所得的聚合材料对L929细胞显示出低细胞毒性，证明了其在生物医学应用中的潜力。这类包含阳离子侧链的材料被束缚到生物相容性和可生物降解的片段上，可能成为有望成为药物和基因传递系统候选人的基础。