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The role of in utero endotoxin exposure in the development of inflammatory bowel disease in mice.
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2020-07-14 , DOI: 10.1111/aji.13302
Emilyn Banfield 1 , William Fulton 2 , Irina Burd 3 , Mark L Kovler 2 , Chhinder P Sodhi 2 , David J Hackam 1, 2
Affiliation  

Although early environmental influences are thought to influence the development of inflammatory bowel disease (IBD), little is known about the role of the in utero environment on subsequent IBD risk. We hypothesized that prenatal exposure to bacterial lipopolysaccharide (LPS) could modify the subsequent development of dextran sulfate sodium (DSS)‐induced ulcerative colitis in adulthood by influencing the associated cellular and immune response.

中文翻译:

子宫内毒素暴露在小鼠炎症性肠病发展中的作用。

尽管早期环境影响被认为会影响炎症性肠病 (IBD) 的发展,但人们对子宫内环境对后续 IBD 风险的影响知之甚少。我们假设产前接触细菌脂多糖(LPS)可以通过影响相关的细胞和免疫反应来改变成年期葡聚糖硫酸钠(DSS)诱导的溃疡性结肠炎的后续发展。
更新日期:2020-07-14
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