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Gli1+ Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation.
Stem Cell Reports ( IF 5.9 ) Pub Date : 2020-07-14 , DOI: 10.1016/j.stemcr.2020.06.007
Ji Chen 1 , Meng Li 2 , An-Qi Liu 2 , Chen-Xi Zheng 2 , Li-Hui Bao 3 , Kai Chen 3 , Xiao-Lin Xu 3 , Jiang-Tao Guan 3 , Meng Bai 3 , Tao Zhou 3 , Bing-Dong Sui 2 , De-Hua Li 4 , Yan Jin 2 , Cheng-Hu Hu 3
Affiliation  

Mesenchymal stem/stromal cells (MSCs) reside in the perivascular niche and modulate tissue/organ homeostasis; however, little is known about whether and how their localization and function are linked. Particularly, whether specific MSC subsets couple with and regulate specialized vessel subtypes is unclear. Here, we show that Gli1+ cells, which are a subpopulation of MSCs couple with and regulate a specialized form of vasculature. The specific capillaries, i.e., CD31hiEMCNhi type H vessels, are the preferable vascular subtype which Gli1+ cells are adjacent to in bone. Gli1+ cells are further identified to be phenotypically coupled with type H endothelium during bone growth and defect healing. Importantly, Gli1+ cell ablation inhibits type H vessel formation associated with suppressed bone generation and regeneration. Mechanistically, Gli1+ cells initiate angiogenesis through Gli and HIF-1α signaling. These findings suggest a morphological and functional framework of Gli1+ cells modulating coupled type H vasculature for tissue homeostasis and regenerative repair.



中文翻译:

Gli1 +细胞与H型血管结合,是H型血管形成所必需的。

间充质干/基质细胞(MSCs)驻留在血管周围的壁iche中,并调节组织/器官的动态平衡。但是,关于它们的定位和功能是否以及如何链接的了解甚少。特别地,尚不清楚特定的MSC亚群是否与特定的血管亚型相结合并对其进行调节。在这里,我们显示了Gli1 +细胞,它是MSC的一个亚群,并能调节特定形式的脉管系统。特定的毛细管,即CD31 hi EMCN hi H型血管是骨中Gli1 +细胞相邻的优选血管亚型。Gli1 +在骨生长和缺陷愈合期间,进一步鉴定出这些细胞在表型上与H型内皮细胞偶联。重要的是,Gli1 +细胞消融可抑制与抑制的骨生成和再生有关的H型血管形成。从机制上讲,Gli1 +细胞通过Gli和HIF-1α信号启动血管生成。这些发现表明,Gli1 +细胞的形态和功能框架可调节H型脉管系统的组织动态平衡和再生修复。

更新日期:2020-07-14
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