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Reproductive outcome after early pregnancy loss treated with misoprostol versus surgical aspiration.
Reproductive BioMedicine Online ( IF 4 ) Pub Date : 2020-07-14 , DOI: 10.1016/j.rbmo.2020.07.004
Yossi Mizrachi 1 , Emilie Ben-Ezry 1 , Ilia Kleiner 1 , Gil Friedman 1 , Ram Kerner 1 , Jacob Bar 1 , Arieh Raziel 1 , Ariel Weissman 1 , Ron Sagiv 1
Affiliation  

Research question

Does long-term reproductive outcome after early pregnancy loss (EPL) differ between women who are treated with misoprostol and surgical aspiration.

Design

A historic cohort study of all women who were diagnosed with early pregnancy loss (≤12 weeks), in a single medical centre, between September 2016 and August 2017, was conducted. The women were treated with either misoprostol or surgical aspiration according to their own preferences. Women who were lost to follow-up or did not attempt to conceive again were excluded. The primary outcome measure was the cumulative pregnancy rate within 12 months from intervention.

Results

Baseline characteristics were comparable between women who received misoprostol (n = 163) and women who underwent surgical aspiration (n = 122). Women who received misoprostol had a higher rate of interventions for retained products of conception (11.0% versus 3.3%, respectively; P = 0.015). The misoprostol and the surgical aspiration groups did not differ in rate of repeated miscarriages (17.8% versus 21.3%, respectively; P = 0.45), or pregnancy rate within 6 months (58.3% versus 50.0%, respectively; P = 0.16), 12 months (78.5% versus 78.7%, respectively; P = 0.97) and 24 months (92.0% versus 91.8%, respectively; P = 0.94). Live birth rate within 24 months was comparable (62.0% versus 58.2%, respectively; P = 0.52), as well as gestational age at birth (38.5 versus 38.6 weeks, respectively; P = 0.81) and birthweight (3295 versus 3161 g, respectively; P = 0.07).

Conclusions

Long-term reproductive outcomes are comparable in women with EPL who are treated with either misoprostol or surgical aspiration. Our findings may help counselling patients facing EPL who have concerns about their future reproduction.



中文翻译:

米索前列醇与手术抽吸治疗早期流产后的生殖结果。

研究问题

接受米索前列醇治疗和手术抽吸治疗的女性在早期流产 (EPL) 后的长期生殖结果是否不同。

设计

对 2016 年 9 月至 2017 年 8 月期间在单一医疗中心被诊断为早期流产(≤12 周)的所有女性进行了历史性队列研究。这些妇女根据自己的喜好接受了米索前列醇或手术抽吸治疗。失访或未尝试再次受孕的女性被排除在外。主要结局指标是干预后 12 个月内的累积妊娠率。

结果

接受米索前列醇治疗的女性 ( n  = 163) 和接受手术抽吸的女性 ( n  = 122) 的基线特征具有可比性。接受米索前列醇的妇女对保留的受孕产物进行干预的比率更高(分别为 11.0% 和 3.3%;P  = 0.015)。米索前列醇组和手术抽吸组在重复流产率(分别为 17.8% 和 21.3%;P  = 0.45)或 6 个月内妊娠率(分别为 58.3% 和 50.0%;P  = 0.16)方面没有差异,12个月(分别为 78.5% 和 78.7%;P  = 0.97)和 24 个月(分别为 92.0% 和 91.8%;P = 0.94)。24 个月内的活产率(分别为 62.0% 和 58.2%;P  = 0.52)以及出生胎龄(分别为 38.5 和 38.6 周;P  = 0.81)和出生体重(分别为 3295 和 3161 克)相当;P  = 0.07)。

结论

接受米索前列醇或手术抽吸治疗的 EPL 女性的长期生殖结果相当。我们的研究结果可能有助于为面临 EPL 的患者提供咨询,这些患者担心他们未来的生育。

更新日期:2020-07-14
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