Group A Streptococcus is a common pathogen that elicits a protective humoral response against the cell wall component GlcNAc. In this issue of Immunity, New et al. demonstrate the ability of long-lived B-1 cells to be programmed by microbial colonization and early life immunization to uniquely incorporate GlcNAc reactivity in mice, establishing their critical role in mediating neonatal immune imprinting.

中文翻译：

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B-1细胞携带了新生儿免疫印迹的记忆。

A组链球菌是一种常见的病原体，可引起针对细胞壁成分GlcNAc的保护性体液反应。在本期《免疫》中，New等人。证明了通过细菌定植和早期免疫程序对长寿B-1细胞进行编程以独特地在小鼠中纳入GlcNAc反应性的能力，确立了它们在介导新生儿免疫印迹中的关键作用。