Functional carbohydrate polymers are of immense industrial interest for high value applications. Distinct biosynthetic pathways allow for metabolic engineering approaches for production in microbial cell factories. The most common strategies in recent years included the attenuation of central carbon metabolism, improved substrate utilization or enhanced intracellular sugar nucleotide precursor levels. Recombinant expression in more suitable surrogate host organisms has demonstrated remarkable results for the heterologous production of glycosaminoglycans. However, industrial application of pharmacological active functional polysaccharides is often limited by costly post-polymerization modifications and downstream processing. With increasing knowledge of bottleneck enzymes and fluxes, it will be possible to enable a sustainable microbial production of high value polysaccharides and tailor artificial polymers towards specific applications.

功能性碳水化合物聚合物对于高价值应用具有巨大的工业价值。不同的生物合成途径允许在微生物细胞工厂中生产代谢工程方法。近年来最常见的策略包括减弱中央碳代谢，提高底物利用率或提高细胞内糖核苷酸前体水平。在更合适的替代宿主生物中的重组表达已证明了异源产生糖胺聚糖的显着结果。然而，药理活性功能多糖的工业应用通常受到昂贵的后聚合修饰和下游加工的限制。随着瓶颈酶和通量知识的增加，