Recent evidence in humans and mice supports the notion that mitochondrial metabolism is active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism by providing key metabolites for macromolecule synthesis and generating oncometabolites to maintain the cancer phenotype. Moreover, there are multiple clinical trials testing the efficacy of inhibiting mitochondrial metabolism as a new cancer therapeutic treatment. In this review, we discuss the rationale of using these anti-cancer agents in clinical trials and highlight how to effectively utilize them in different tumor contexts.

中文翻译：

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线粒体代谢作为癌症治疗的目标。

最近在人类和小鼠身上的证据支持这样的观点：线粒体代谢是活跃的并且是肿瘤生长所必需的。线粒体代谢通过为大分子合成提供关键代谢物并产生肿瘤代谢物以维持癌症表型来支持肿瘤合成代谢。此外，还有多项临床试验测试了抑制线粒体代谢作为新的癌症治疗方法的功效。在这篇综述中，我们讨论了在临床试验中使用这些抗癌药物的基本原理，并强调如何在不同的肿瘤环境中有效地利用它们。