Abstract

Molecules possessing harmine moiety are reported to exhibit marked fungicidal and bactericidal activities. In this study, various quinozilinium tetrafluoroborate salts were synthesized using acylic and cyclic oxoketene dithioacetals followed by cycloaromatization from Harmine. All of these synthesized compounds were characterized by ¹H NMR, ¹³C NMR, Mass and CHN analysis. This methodology would find wide usage in the preparation of indolo quinozilinium -based library of small molecules useful for medicinal chemistry and in drug discovery.

Graphic abstract

中文翻译：

---

甘氨酸合成氟硼酸喹唑啉鎓盐

摘要

据报道，具有甜菜碱部分的分子表现出显着的杀真菌和杀菌活性。在这项研究中，使用酰基和环状氧杂环丁烯二硫缩醛，然后从Harmine进行环芳化，合成了各种喹唑鎓四氟硼酸盐。所有这些合成的化合物均通过¹ H NMR，¹³ C NMR，质量和CHN分析进行表征。该方法将在制备基于吲哚喹喔啉的小分子文库中得到广泛使用，该文库可用于药物化学和药物开发。

图形摘要