当前位置: X-MOL 学术J. Chem. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Design and synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives via click reactions
Journal of Chemical Research ( IF 1.4 ) Pub Date : 2020-05-27 , DOI: 10.1177/1747519820919853
Tong Lu 1 , Ling Dong 2 , Hongmei Pan 1 , Xuedan Wu 1 , Xia Chen 1 , Chengwen Gu 1 , Naili Tao 1 , Ao Wang 1 , Kehua Zhang 1 , Jie Jin 1
Affiliation  

The synthesis of C-ring quinoxaline-substituted sinomenine 1,2,3-triazole derivatives at the 4-OH via click reactions is accomplished, and a total of 16 novel sinomenine double N-heterocyclic derivatives are obtained in 74%–95% yields. The C-ring is first transformed into a 1,2-diketone structure under the action of hydrochloric acid, and then reacted with o-phenylenediamine to obtain a C-ring quinoxaline-substituted structure. The 4-OH of sinomenine reacts with chloropropyne to give an alkynyl sinomenine, and then reacts with sodium azide and various benzyl chlorides to give the target compounds. All the synthesized derivatives are characterized by Fourier-transform infrared spectrometry, high resolution mass spectrometry, 1H NMR, and 13C NMR spectroscopy.

中文翻译:

C环喹喔啉取代青藤碱1,2,3-三唑衍生物的点击反应设计合成

通过点击反应在4-OH上合成了C环喹喔啉取代的青藤碱1,2,3-三唑衍生物,共获得16种新型青藤碱双N-杂环衍生物,产率74%~95% . C环在盐酸作用下先转变为1,2-二酮结构,再与邻苯二胺反应得到C环喹喔啉取代结构。青藤碱的4-OH与氯丙炔反应生成炔基青藤碱,然后与叠氮化钠和各种苄基氯反应生成目标化合物。所有合成的衍生物均通过傅里叶变换红外光谱、高分辨率质谱、1H NMR 和 13C NMR 光谱进行表征。
更新日期:2020-05-27
down
wechat
bug