As a cavitation enhancer, low boiling point phase‐change contrast agents (PCCA) offer potential for ultrasound‐mediated drug delivery in applications including intracerebral hemorrhage or brain tumors. In addition to introducing cavitation, ultrasound imaging also has the ability to provide guidance and monitoring of the therapeutic process by localizing delivery events. However, the highly attenuating skull poses a challenge for achieving an image with useful contrast. In this study, the feasibility of transcranial activation and imaging of low boiling point PCCAs through the human temporal bone was investigated by using a low frequency ultrafast interframe activation ultrasound (UIAU) imaging sequence with singular value decomposition‐based denoising.

中文翻译：

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使用超快速帧间激活超声序列经颅骨通过颅骨激活低沸点相变造影剂并进行成像。

作为空化增强剂，低沸点相变造影剂（PCCA）为包括脑出血或脑肿瘤在内的应用提供了超声介导的药物输送潜力。除了引入空化作用，超声成像还具有通过定位输送事件来提供治疗过程的指导和监测的能力。然而，高度衰减的头骨对获得具有有用对比度的图像提出了挑战。在这项研究中，通过使用低频超快帧间激活超声（UIAU）成像序列和基于奇异值分解的降噪技术，研究了通过颅骨激活低沸点PCCA并通过人类颞骨成像的可行性。