Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly comprises the actin microfilaments, microtubules, and intermediate filaments. During migration, cells polarize and form protrusions at the front, where new adhesions are formed. These nascent adhesions mature into focal adhesions that transmit the traction forces required for movement. All of these steps are coupled to major cytoskeletal rearrangements and are controlled by a wide array of signaling cascades. The constant crosstalk between actin, microtubules, and intermediate filaments ensures their coordinated dynamics to facilitate cell migration. Here, we first describe how master regulators, such as RhoGTPases, can simultaneously control the three cytoskeletal structures. We then summarize the recent crosstalk mechanisms by which cytoskeletal networks can locally regulate one another in order to function in a coordinated and efficient manner during migration.

细胞迁移是由细胞骨架驱动的高度动态的过程，其主要包括肌动蛋白微丝，微管和中间丝。在迁移过程中，细胞会极化并在前部形成突起，从而形成新的粘连。这些新生的粘连成熟成粘着粘连，传递运动所需的牵引力。所有这些步骤都与主要的细胞骨架重排有关，并受多种信号级联的控制。肌动蛋白，微管和中间丝之间不断的串扰，确保它们协调的动力学，以促进细胞迁移。在这里，我们首先描述主调节器（例如RhoGTPases）如何同时控制三个细胞骨架结构。