This study explores the efficacy and mechanism by which octreotide (OCT) alleviates paraquat (PQ)-induced pancreatic injury. Twenty-four adult male rats were randomly divided into three groups: the normal control (NC), PQ poisoning, and OCT treatment groups. The PQ-induced pancreatic injury rat model was established by administering PQ (120 mg/kg). Treatment group rats received OCT (8 μg/kg body weight) every 8 h by subcutaneous injection, 1 h after PQ administration. Rats were euthanized 24 h after PQ injection. Serum amylase, lipase, tumor necrosis factor-α, and interleukin-6 levels were markedly increased in the PQ group versus the NC group. In pancreatic tissue, PQ poisoning drastically induced necrosis and increased inflammatory cytokine and oxidative stress marker levels. Compared with the PQ group, OCT reduced pancreatic damage and histological scores, serum amylase, lipase, and inflammatory cytokine levels, as well as oxidative stress. OCT demonstrates protective effects against PQ-induced pancreatic damage through anti-inflammatory and antioxidant actions.

本研究探讨了奥曲肽（OCT）减轻百草枯（PQ）引起的胰腺损伤的功效和机理。将24只成年雄性大鼠随机分为三组：正常对照组（NC），PQ中毒和OCT治疗组。通过施用PQ（120 mg / kg）建立PQ诱发的胰腺损伤大鼠模型。治疗组大鼠在PQ给药后1小时，每8小时皮下注射一次接受OCT（8μg/ kg体重）。PQ注射后24小时对大鼠实施安乐死。与NC组相比，PQ组的血清淀粉酶，脂肪酶，肿瘤坏死因子-α和白介素-6水平显着升高。在胰腺组织中，PQ中毒会导致坏死，并增加炎症细胞因子和氧化应激标记物的水平。与PQ组相比 OCT降低了胰腺损伤和组织学评分，血清淀粉酶，脂肪酶和炎性细胞因子水平，以及氧化应激。OCT通过抗炎和抗氧化作用证明对PQ诱导的胰腺损伤具有保护作用。