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Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses.
Environmental Pollution ( IF 8.9 ) Pub Date : 2020-07-13 , DOI: 10.1016/j.envpol.2020.115148
Richa Mishra 1 , Pandikannan Krishnamoorthy 1 , S Gangamma 2 , Ashwin Ashok Raut 3 , Himanshu Kumar 4
Affiliation  

Sensing of pathogens by specialized receptors is the hallmark of the innate immunity. Innate immune response also mounts a defense response against various allergens and pollutants including particulate matter present in the atmosphere. Air pollution has been included as the top threat to global health declared by WHO which aims to cover more than three billion people against health emergencies from 2019 to 2023. Particulate matter (PM), one of the major components of air pollution, is a significant risk factor for many human diseases and its adverse effects include morbidity and premature deaths throughout the world. Several clinical and epidemiological studies have identified a key link between the PM existence and the prevalence of respiratory and inflammatory disorders. However, the underlying molecular mechanism is not well understood. Here, we investigated the influence of air pollutant, PM10 (particles with aerodynamic diameter less than 10 μm) during RNA virus infections using highly pathogenic avian influenza (HPAI) – H5N1 virus. We thus characterized the transcriptomic profile of lung epithelial cell line, A549 treated with PM10 prior to H5N1infection, which is known to cause severe lung damage and respiratory disease. We found that PM10 enhances vulnerability (by cellular damage) and regulates virus infectivity to enhance overall pathogenic burden in the lung cells. Additionally, the transcriptomic profile highlights the connection of host factors related to various metabolic pathways and immune responses which were dysregulated during virus infection. Collectively, our findings suggest a strong link between the prevalence of respiratory illness and its association with the air quality.



中文翻译:

颗粒物(PM10)通过调节先天免疫应答来增强RNA病毒感染。

通过专门受体感知病原体是先天免疫的标志。天生的免疫反应还可以抵抗各种过敏原和污染物,包括大气中存在的颗粒物。世卫组织宣布,空气污染已被列为对全球健康的最大威胁,其目标是在2019年至2023年期间应对超过30亿人的健康突发事件。空气污染的主要成分之一-颗粒物(PM)是重要的许多人类疾病的危险因素及其不利影响包括全世界的发病率和过早死亡。几项临床和流行病学研究已经确定了PM的存在与呼吸道疾病和炎性疾病的流行之间的关键联系。然而,潜在的分子机制还没有被很好地理解。这里,使用高致病性禽流感(HPAI)– H5N1病毒感染RNA病毒期间感染10粒(空气动力学直径小于10μm的颗粒)。因此,我们表征了肺上皮细胞系A549在H5N1感染之前用PM 10处理的转录组谱,已知这会引起严重的肺损伤和呼吸系统疾病。我们发现10号纸机通过细胞损伤增强脆弱性,并调节病毒的感染性,从而增强肺细胞的总体致病性负担。另外,转录组谱突出显示了与各种代谢途径和免疫反应有关的宿主因子的连接,这些途径在病毒感染期间失调。总体而言,我们的发现表明,呼吸系统疾病的流行与其空气质量之间的联系密切。

更新日期:2020-07-13
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