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The omentum harbors unique conditions in the peritoneal cavity to promote healing and regeneration for diaphragm muscle repair in mdx mice
Cell and Tissue Research ( IF 3.6 ) Pub Date : 2020-07-13 , DOI: 10.1007/s00441-020-03238-1
Jaciara F G Gama 1, 2 , Douglas Florindo Pinheiro 2 , Rafael Ferreira Da Silva 1 , Thereza Quirico-Santos 1, 2 , Jussara Lagrota-Candido 2
Affiliation  

Although the primary cause of Duchenne muscular dystrophy (DMD) is a genetic mutation, the inflammatory response contributes directly to severity and exacerbation of the diaphragm muscle pathology. The omentum is a lymphoid organ with unique structural and immune functions serving as a sanctuary of hematopoietic and mesenchymal progenitors that coordinate immune responses in the peritoneal cavity. Upon activation, these progenitors expand and the organ produces large amounts of growth factors orchestrating tissue regeneration. The omentum of mdx mouse, a DMD murine model, is rich in milky spots and produces growth factors that promote diaphragm muscle regeneration. The present review summarizes the current knowledge of the omentum as an important immunologic structure and highlights its contribution to resolution of dystrophic muscle injury by providing an adequate environment for muscle regeneration, thus being a potential site for therapeutic interventions in DMD.

中文翻译:

大网膜在腹腔中具有独特的条件,可促进 mdx 小鼠隔膜肌肉修复的愈合和再生

虽然杜氏肌营养不良症 (DMD) 的主要原因是基因突变,但炎症反应直接导致膈肌病理的严重程度和恶化。大网膜是一种淋巴器官,具有独特的结构和免疫功能,是协调腹腔内免疫反应的造血和间充质祖细胞的庇护所。激活后,这些祖细胞会膨胀,器官会产生大量的生长因子来协调组织再生。mdx 小鼠的网膜,鼠类 DMD 模型,富含乳斑,并产生促进膈肌再生的生长因子。
更新日期:2020-07-13
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