Abstract Nrf2 is a key transcription factor responsible for antioxidant defense in many tissues and cells, including alveolar epithelium, endothelium, and macrophages. Furthermore, Nrf2 functions as a transcriptional repressor that inhibits expression of the inflammatory cytokines in macrophages. Critically ill patients with COVID-19 infection often present signs of high oxidative stress and systemic inflammation – the leading causes of mortality. This article suggests rationale for the use of Nrf2 inducers to prevent development of an excessive inflammatory response in COVID-19 patients.

中文翻译：

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转录因子 Nrf2 作为预防 COVID-19 患者细胞因子风暴的潜在治疗靶点

摘要 Nrf2 是在许多组织和细胞中负责抗氧化防御的关键转录因子，包括肺泡上皮、内皮和巨噬细胞。此外，Nrf2 作为转录抑制因子发挥作用，抑制巨噬细胞中炎性细胞因子的表达。感染 COVID-19 的重症患者通常会出现高氧化应激和全身炎症的迹象——这是导致死亡的主要原因。本文提出了使用 Nrf2 诱导剂来防止 COVID-19 患者发生过度炎症反应的基本原理。