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Patterns of olfactory dysfunctions in patients with Parkinson disease
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Pub Date : 2020-07-10 , DOI: 10.1186/s41983-020-00205-z
Khaled Hussein Rashed , Wafik Said Bahnasy , Yasser Abo Elfotoh El-Heneedy , Ehab Ahmed Shawky El-Seidy , Mohamed Osama Tomoum , Mohamed Adel Eltomey , Shereen Ahmed ELAhwal

Background Olfactory dysfunction (OD) is a well-established nonmotor manifestations (NMM) of Parkinson disease (PD) which needs objective assessment for better understanding of the disease pathogenesis. The aim of this work was quantitative and qualitative assessment of olfactory performance in newly diagnosed PD patients. Methods This study was performed on 32 recently diagnosed PD patients and 24 healthy controls subjects (HCS) submitted to unified Parkinson’s disease rating scale–III (UPDRS–III), extended n-butanol Sniffin’ Sticks test (SST) and olfactory bulbs volumetry (OBV). Results There were significant decreases in SST threshold, discrimination, identification, and TDI variables as well as OBV in PD patients compared to HCS. The olfactory performance was negatively correlated with disease duration but had no relation with PD severity as well as motor subtype. Conclusion OD is highly prevalent during the early stages of PD which is both measurable and specific with identification and discrimination impairments to certain odors which makes smell performance testing an important step in PD patients’ evaluation.

中文翻译:

帕金森病患者嗅觉障碍的模式

背景嗅觉功能障碍 (OD) 是帕金森病 (PD) 的一种公认的非运动表现 (NMM),需要进行客观评估以更好地了解疾病的发病机制。这项工作的目的是对新诊断的 PD 患者的嗅觉表现进行定量和定性评估。方法 本研究对 32 名最近诊断的 PD 患者和 24 名健康对照受试者 (HCS) 进行,这些受试者接受统一的帕金森病评定量表–III (UPDRS–III)、扩展的正丁醇 Sniffin' Sticks 测试 (SST) 和嗅球体积测量。 OBV)。结果 与 HCS 相比,PD 患者的 SST 阈值、鉴别、识别和 TDI 变量以及 OBV 显着降低。嗅觉表现与病程呈负相关,但与 PD 严重程度和运动亚型无关。结论 OD 在 PD 的早期阶段非常普遍,它既可测量又具有特异性,对某些气味的识别和辨别障碍使嗅觉性能测试成为 PD 患者评估的重要步骤。
更新日期:2020-07-10
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