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Phage steering of antibiotic-resistance evolution in the bacterial pathogen, Pseudomonas aeruginosa
Evolution, Medicine, and Public Health ( IF 5.143 ) Pub Date : 2020-07-11 , DOI: 10.1093/emph/eoaa026
James Gurney 1, 2 , Léa Pradier 3 , Joanne S Griffin 4 , Claire Gougat-Barbera 5 , Benjamin K Chan 6 , Paul E Turner 6, 7 , Oliver Kaltz 5 , Michael E Hochberg 5, 8
Affiliation  

Antimicrobial resistance is a growing global concern and has spurred increasing efforts to find alternative therapeutics. Bacteriophage therapy has seen near constant use in Eastern Europe since its discovery over a century ago. One promising approach is to use phages that not only reduce bacterial pathogen loads but also select for phage resistance mechanisms that trade-off with antibiotic resistance—so called ‘phage steering’.

中文翻译:

细菌病原体中抗生素抗性进化的噬菌体控制,铜绿假单胞菌

抗菌素耐药性是一个日益严重的全球问题,并促使人们越来越多地努力寻找替代疗法。自一个多世纪前发现以来,噬菌体疗法在东欧几乎一直在使用。一种有前途的方法是使用噬菌体,不仅可以减少细菌病原体的负荷,而且可以选择与抗生素耐药性相权衡的噬菌体耐药机制——所谓的“噬菌体转向”。
更新日期:2020-07-11
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