Misregulation of signaling pathway activity is etiologic for many human diseases, and modulating activity of signaling pathways is often the preferred therapeutic strategy. Understanding the mechanism of action (MOA) of bioactive chemicals in terms of targeted signaling pathways is the essential first step in evaluating their therapeutic potential. Changes in signaling pathway activity are often not reflected in changes in expression of pathway genes which makes MOA inferences from transcriptional signatures a difficult problem.

中文翻译：

---

预测具有通路活性特征的细胞扰动的作用机理。

信号通路活性的失调是许多人类疾病的病因，而调节信号通路的活性通常是首选的治疗策略。了解有针对性的信号传导途径的生物活性化学物质的作用机理（MOA）是评估其治疗潜力的重要第一步。信号转导途径活性的变化通常不能反映在途径基因表达的变化中，这使得从转录特征中推断出MOA成为一个难题。