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Functional and behavioral signatures of Kv7 activator drug subtypes
Epilepsia ( IF 5.6 ) Pub Date : 2020-07-11 , DOI: 10.1111/epi.16592 Richard Kanyo 1 , Caroline K Wang 2 , Laszlo F Locskai 1 , Jingru Li 2 , W Ted Allison 1 , Harley T Kurata 2
Epilepsia ( IF 5.6 ) Pub Date : 2020-07-11 , DOI: 10.1111/epi.16592 Richard Kanyo 1 , Caroline K Wang 2 , Laszlo F Locskai 1 , Jingru Li 2 , W Ted Allison 1 , Harley T Kurata 2
Affiliation
Voltage‐gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional criteria for categorization of Kv7 activator compounds, and to compare the effects of prototypical drugs in a zebrafish larvae model.
中文翻译:
Kv7 激活剂药物亚型的功能和行为特征
KCNQ(Kv7)家族的电压门控钾通道被多种具有治疗癫痫潜力的活化剂化合物靶向。对该类药物的探索揭示了具有不同机制的多种有效化合物。在本研究中,我们旨在阐明 Kv7 激活剂化合物分类的功能标准,并比较原型药物在斑马鱼幼虫模型中的作用。
更新日期:2020-07-11
中文翻译:
Kv7 激活剂药物亚型的功能和行为特征
KCNQ(Kv7)家族的电压门控钾通道被多种具有治疗癫痫潜力的活化剂化合物靶向。对该类药物的探索揭示了具有不同机制的多种有效化合物。在本研究中,我们旨在阐明 Kv7 激活剂化合物分类的功能标准,并比较原型药物在斑马鱼幼虫模型中的作用。