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Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks.
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2020-07-10 , DOI: 10.1016/j.tibs.2020.06.001
Xin Zhou 1 , Sohum Mehta 1 , Jin Zhang 1
Affiliation  

Cell signaling networks are intricately regulated in time and space to determine the responses and fates of cells to different cues. Genetically encodable fluorescent and bioluminescent biosensors enable the direct visualization of these spatiotemporal signaling dynamics within the native biological context, and have therefore become powerful molecular tools whose unique benefits are being used to address challenging biological questions. We first review the basis of biosensor design and remark on recent technologies that are accelerating biosensor development. We then discuss a few of the latest advances in the development and application of genetically encodable fluorescent and bioluminescent biosensors that have led to scientific or technological breakthroughs.



中文翻译:

可遗传编码的荧光和生物发光生物传感器点亮信号网络。

细胞信号网络在时间和空间上受到错综复杂的调节,以确定细胞对不同线索的反应和命运。可遗传编码的荧光和生物发光生物传感器能够在天然生物环境中直接可视化这些时空信号动力学,因此已成为强大的分子工具,其独特的优势被用于解决具有挑战性的生物学问题。我们首先回顾了生物传感器设计的基础,并评论了正在加速生物传感器发展的最新技术。然后,我们讨论了导致科学或技术突破的遗传可编码荧光和生物发光生物传感器的开发和应用的一些最新进展。

更新日期:2020-09-18
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