Liposome possesses a great number of advantages and therefore they can be used for a variety of applications. Among other things, they can serve as useful drug carriers in preclinical and clinical trials. Supercritical fluids assisted technology is an appropriate method for liposome preparation because of its nontoxicity to the environment enables particle size manipulation and solvent-free production. Thus, the use of supercritical fluids (SCFs) provides advanced technology for liposome preparation and may become the dominant technology for their preparation in the future. This review discusses the classification of liposome and gives a short overview of their applications and conventional methods of preparation. Emphasis is placed on the use of various supercritical fluids assisted methods for liposome preparation and their advantages and disadvantages. The reader is also updated about recent developments in supercritical fluids assisted liposome production technology.

脂质体具有许多优点，因此它们可用于多种应用。其中，它们可以在临床前和临床试验中用作有用的药物载体。超临界流体辅助技术是制备脂质体的合适方法，因为它对环境无毒，可以控制粒径并实现无溶剂生产。因此，超临界流体（SCF）的使用为脂质体的制备提供了先进的技术，并可能成为将来制备脂质体的主要技术。这篇综述讨论了脂质体的分类，并简要概述了它们的应用和常规制备方法。重点放在使用各种超临界流体辅助的脂质体制备方法及其优点和缺点上。还向读者介绍了超临界流体辅助脂质体生产技术的最新发展。