Carboxylated bacterial cellulose (OBC) was fabricated by oxidation with nitrogen dioxide in chloroform/cyclohexane and employed as a carrier for sustained release of antitumor substance cisplatin (CDDP). The influence of removing water method, solvent used in the synthesis, concentration of N₂O₄, and duration of the oxidation on content of carboxyl groups in reaction products was established. Due to the possibility of nitrogen dioxide to penetrate into cellulose crystallites, the carboxyl group content of the OBC reaches high values up to 4 mmol/g. In vitro degradation of OBC was determined under simulated physiological conditions. The immobilization of CDDP on OBC was studied in detail. The initial burst release of the drug from the polymer was depressed. The cytotoxicity of CDDP-loaded OBC was evaluated with HeLa cells. The unique structure and properties of OBC make it a great candidate as drug delivery carrier.

羧化细菌纤维素（OBC）是通过在氯仿/环己烷中用二氧化氮氧化制备的，并用作持续释放抗肿瘤物质顺铂（CDDP）的载体。建立了脱水方法，合成中使用的溶剂，N ₂ O _4的浓度以及氧化时间对反应产物中羧基含量的影响。由于二氧化氮可能渗透到纤维素微晶中，OBC的羧基含量高达4 mmol / g。体外在模拟的生理条件下确定了OBC的降解。详细研究了CDDP在OBC上的固定化。药物从聚合物中最初的突释释放受到抑制。用HeLa细胞评估CDDP负载的OBC的细胞毒性。OBC的独特结构和性能使其成为药物输送载体的理想选择。