Alzheimer’s disease (AD) is a growing global healthcare epidemic. Owing to advances in technology, genome‐scale studies of various layers of molecular information have been undertaken in recent years and robust variation in key loci have now been published and reproduced by others. This mini‐symposium highlights four key areas of current research in the field of molecular biology in AD, including articles focused on large‐scale genomic profiling, epigenetic research, integrative multi‐omic approaches and how these can be appropriately modeled to address reverse causality. This mini‐symposium provides a timely update on research focused on elucidating the molecular etiology of AD to date and highlights new methodological advances that could enable neuroscientists to identify novel therapeutic targets.

中文翻译：

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阿尔茨海默病的分子病因学。

阿尔茨海默病 (AD) 是一种日益严重的全球医疗流行病。由于技术的进步，近年来对不同层次的分子信息进行了基因组规模的研究，关键位点的强大变异现已被其他人发表和复制。本次小型研讨会重点介绍了 AD 分子生物学领域当前研究的四个关键领域，包括专注于大规模基因组分析、表观遗传研究、综合多组学方法以及如何对这些方法进行适当建模以解决反向因果关系的文章。本次小型研讨会及时更新了迄今为止专注于阐明 AD 分子病因学的研究，并强调了新的方法学进展，可以使神经科学家确定新的治疗靶点。