Age is the only one non-modifiable risk of cerebral ischemia. Advances in stroke medicine and behavioral adaptation to stroke risk factors and comorbidities was successful in decreasing stroke incidence and increasing the number of stroke survivors in western societies. Comorbidities aggravates the outcome after cerebral ischemia. However, due to the increased in number of elderly, the incidence of stroke has increased again paralleled by an increase in the number of stroke survivors, many with severe disabilities, that has led to an increased economic and social burden in society. Animal models of stroke often ignore age and comorbidities frequently associated with senescence. This might explain why drugs working nicely in animal models fail to show efficacy in stroke survivors. Since stroke afflicts mostly the elderly comorbid patients, it is highly desirable to test the efficacy of stroke therapies in an appropriate animal stroke model. Therefore, in this review, we make parallels between animal models of stroke und clinical data and summarize the impact of ageing and age-related comorbidities on stroke outcome.

年龄是唯一一种不可改变的脑缺血风险。中风医学和行为适应中风危险因素和合并症的进展成功地降低了西方社会的中风发病率并增加了中风幸存者的数量。合并症会加重脑缺血后的预后。然而，由于老年人口增加，中风发病率再次上升，中风幸存者人数增加，其中许多是重度残疾，导致社会经济和社会负担加重。中风的动物模型常常忽略与衰老相关的年龄和合并症。这或许可以解释为什么在动物模型中表现良好的药物未能在中风幸存者中显示出疗效。由于中风主要影响老年合并症患者，非常需要在适当的动物中风模型中测试中风疗法的功效。因此，在这篇综述中，我们将中风动物模型与临床数据进行了比较，并总结了衰老和与年龄相关的合并症对中风结局的影响。