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Control of vessel diameters mediated by flow-induced outward vascular remodeling in vitro.
Biofabrication ( IF 9 ) Pub Date : 2020-07-08 , DOI: 10.1088/1758-5090/ab9316
Hiromu Sano 1 , Masafumi Watanabe , Tadahiro Yamashita , Kazuo Tanishita , Ryo Sudo
Affiliation  

Vascular networks consist of hierarchical structures of various diameters and are necessary for efficient blood distribution. Recent advances in vascular tissue engineering and bioprinting have allowed us to construct large vessels, such as arteries, small vessels, such as capillaries and microvessels, and intermediate-scale vessels, such as arterioles, individually. However, little is known about the control of vessel diameters between small vessels and intermediate-scale vessels. Here, we focus on vascular remodeling, which creates lasting structural changes in the vessel wall in response to hemodynamic stimuli, to regulate vessel diameters in vitro . The purpose of this study is to control the vessel diameter at an intermediate scale by inducing outward remodeling of microvessels in vitro . Human umbilical vein endothelial cells and mesenchymal stem cells were cocultured in a microfluidic device to construct microvessels, which were then perfused with a culture me...

中文翻译:

体外控制由血流诱导的向外血管重塑介导的血管直径。

血管网络由各种直径的层次结构组成,是有效分配血液所必需的。血管组织工程和生物打印的最新进展使我们能够分别构建大血管(例如动脉),小血管(例如毛细管和微血管)和中等规模的血管(例如小动脉)。但是,关于控制小型容器和中型容器之间的容器直径的了解很少。在这里,我们专注于血管重塑,该血管重塑在响应血流动力学刺激的情况下在血管壁上产生持久的结构变化,从而在体外调节血管直径。这项研究的目的是通过诱导体外微血管的外向重塑,将血管直径控制在一个中等水平。
更新日期:2020-07-10
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